Custom Peptides
Cayman Chemical EIcosapentaeNIc ACD mthyl 10mg
An esterified form of EPA; has been used as a reference standard in the quantification of fatty acids in microalgal and fish oils
Cayman Chemical S-2 MethndamIde 10mg
The second most potent CB1 receptor agonist in the methanandamide series (Ki = 26 nM for the CB1 receptor); less prone to FAAH inactivation and inhibits the murine vas deferens twitch response (IC50 = 47 nM)
Cayman Chemical N-ArachIdonylAmInobutyrIc 10mg
Several different arachidonoyl amino acids, including NAGABA, have been isolated and characterized from bovine brain. The glycine congener (NAGly) was found to suppress formalin-induced pain in rats. NAGABA also suppresses normal responses to pain, but has not yet been fully characterized.
Cayman Chemical MItoxntronhydrochlorIde 10mg
An inhibitor of DNA topoisomerase IIα and HIV-1 integrase (IC50s = 5.3 and 3.8 μM, respectively); intercalates DNA in a cell-free assay at 2 µM; inhibits DNA synthesis and induces DNA-protein crosslinks in vitro; inhibits the growth of K562 and K562-derived etoposide-resistant K/VP.5 cells (IC50s = 0.42 and 1.68 µM, respectively); inhibits HIV-1 integrase (IC50 = 3.8 μM); inhibits the membrane fusion of a mixed population of HEK293T cells expressing either ACE2 or the extracellular domain SARS-CoV-2 spike glycoprotein; inhibits the entry of SARS-CoV-2 into Vero E6 cells at 0.2 µM
Cayman Chemical RItalInIc AcId 10mg
An inactive, major metabolite of methylphenidate; intended for forensic and biological research purposes
Cayman Chemical R S-natbIntartrate 10mg
A minor tobacco alkaloid; an agonist of α4β2 and α6/α3β2β4 subunit-containing nAChRs (EC50s = 6.1 and 3.6 µM, respectively); selective for these nAChRs over α3β4 subunit-containing nAChRs or α7 nAChRs (EC50s = 70.6 and 158.5 µM, respectively); stimulates dopamine release from isolated rat brain synaptosomes (EC50s = 1.76 and >100 µM, respectively); has anxiolytic-like activity in zebrafish at 10 mg/L; decreases disease severity in a mouse model of thyroglobulin, CFA, and M. tuberculosis immunization-induced moderate experimental autoimmune thyroiditis; decreases food and nicotine self-administration in monkeys (ED50s = 2.085 and 0.854 mg/kg, respectively); has been used as a biomarker of tobacco use
Cayman Chemical JPH203hydrochlorIde 10mg
An inhibitor of LAT1 (IC50 = 0.14 μM for 14C-leucine uptake in S2 cells expressing the human transporter); selective for LAT1 over LAT2 (IC50 = >10 μM); inhibits 14C-leucine uptake by, and growth of, HT-29 cells (IC50s = 0.06 and 4.1 μM, respectively); induces apoptosis and increases levels of cleaved caspase-3, caspase-7, caspase-9, and PARP in YD-38 oral cancer cells at 3 mM; reduces tumor growth in an HT-29 mouse xenograft model at 6.3, 12.5, and 25 mg/kg
Cayman Chemical Gelsemum elegns Koumn 10mg
An alkaloid with diverse biological activities; inhibits the proliferation of MCF-7 cells (IC50 = 124 UG/ml) as well as induces apoptosis and cell cycle arrest at the G2/M phase in the same cells; reduces LPS-induced increases in iNOS, IL-1β, IL-6, and TNF-α levels in RAW 264.7 macrophages at 200 and 400 UG/ml; inhibits acetic acid-induced writhing and formalin-induced paw licking and biting in mice at 2 and 10 mg/kg; increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, at 0.4-10 mg/kg
Cayman Chemical DesoxImetason 10mg
A glucocorticoid; reverses TPA-induced increases in epidermal cell proliferation in SENCAR mice (0.001-0.1 mg topically); reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice
Cayman Chemical EvacetrapIb 10mg
A benzazepine-based inhibitor of CETP (IC50s = 5.5 and 26 nM for human recombinant and plasma-derived proteins, respectively); selective for CETP over a panel of cell surface and nuclear receptors at 1 µM; reduces expression of PCSK9 and LDLR in HepG2 cells in a dose-dependent manner; reduces protein levels of LDLR, SREBF2-M, and PCSK9 in HepG2 lysates, nuclear extracts, and culture medium, respectively, in a dose-dependent manner; inhibits CETP activity by 98.5, 98.6, and 18.4% at four, eight, and 24 h, respectively, in CETP/ApoA1 transgenic mice at 30 mg/kg; increases HDL cholesterol levels in serum from CETP/ApoA1 transgenic mice in a dose-dependent manner, including by 129.7% eight hours after a 30 mg/kg dose
Cayman Chemical xabeplon 10mg
A broad-spectrum anticancer agent; active against a panel of 21 cancer cell lines (IC50s = 1.4-34.5 nM); stabilizes and induces the polymerization of microtubules and induces cell cycle arrest during mitosis; cytotoxic to paclitaxel-resistant HCT116/VM46 and A2780Tax clonogenic cells (IC90s = 16 and 12.3 nM, respectively, for colony growth inhibition); shows antitumor activty in paclitaxel-resistant human Pat-21 breast carcinoma and HCT116/VM46 colon carcinoma mouse xenograft models (LCKs = 1.6 and 2.4, respectively); increases the time for tumors to quadruple in volume in mice implanted with Rh18 rhabdomyosarcoma, NB1643 neuroblastoma, WT5 Wilms' tumor, OS29 osteosarcoma, and BT29 brain carcinoma cells at 10 mg/kg
Cayman Chemical 5trns Fluprostnl Isopropy 10mg
A potential impurity in commercial preparations of travoprost
Cayman Chemical AzurIn50-77PaerugInosa 10mg
A peptide; inhibitor of VEGFR2 (IC20 = ~10.7 µM); induces cell cycle arrest at the G2/M phase in MCF-7 cells at 20 µM; reduces MCF-7 and ZR-75-1 cancer cell proliferation at 50 µM; reduces VEGF-A-induced capillary tube formation (IC50 = 12 µM), as well as decreases cell-membrane associated levels of F-actin, FAK, and paxillin and increases extracellular levels of PECAM-1 in HUVECs at 25 µM; reduces tumor volume in an MCF-7 mouse xenograft model at 10 mg/kg per day
Cayman Chemical RubIadIn-1 methyl ether 10mg
An anthraquinone with diverse biological activities; generates superoxide radicals in isolated human neutrophils and monocytes at 20 UG/ml, an effect that can be enhanced by UV radiation; inhibits M-CSF- and RANKL-induced differentiation of osteoclasts at 0.1, 1, and 10 µM; inhibits C. tropicalis biofilm formation (MIC = 31.3 UG/ml for a clinical isolate); reduces LPS-induced increases in BALF levels of TNF-α, IL-6, and IFN-γ in a mouse model of acute lung injury at 30 mg/kg
Cayman Chemical LIdocaIn-d10 10mg
An internal standard for the quantification of lidocaine by GC- or LC-MS